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The progestogenic effect is not required in hysterectomised women and may cause unnecessary adverse effects. Note 4: compounded bioidentical testosterone. Hormone therapy lowers the amount of testosterone in the body and this affects your ability to have and maintain an erection. This may get better within 3 to 12. Treatment with testosterone could help tackle depression in men, according to a review of studies which found supplements of the hormone. Serum levels of total testosterone, free testosterone,. They demonstrated that overall there was a minimal effect of induced testosterone deficiency on mood, though the testosterone-deficient state. Prostate cancer cells need testosterone to grow and spread. Side effects can include sexual dysfunction, weight gain and fatigue. There is a clear link between low testosterone and depression 2. All medications have potential side-effects. 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